Article
Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells.
The Journal of clinical investigation - 1 May 1994
Muglia L J, Jenkins N A, Gilbert D J, Copeland N G, Majzoub J A
Abstract excerpt
Corticotropin-releasing hormone (CRH), one of the primary regulators of the hypothalamic-pituitary-adrenal (HPA) axis, exhibits abnormal regulation in pathologic states such as depression and anorexia nervosa. Analysis of the role of CRH in regulation of the HPA axis would be facilitated by the c...
Topics
- Animals
- Base Sequence
- Chimera
- Chromosome Mapping
- Cloning, Molecular
- Corticotropin-Releasing Hormone
- Crosses, Genetic
- Female
- Gene Expression Regulation
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- RNA, Messenger
- Stem Cells