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Article

Responses to Bordetella pertussis mutant strains and to vaccination in the coughing rat model of pertussis.

Journal of medical microbiology - 1 May 1994

Parton R, Hall E, Wardlaw A C

Abstract excerpt

Phase I strains 18-323, Tohama and L-84 of Bordetella pertussis produced paroxysmal coughing when encased in agarose beads and administered intrabronchially to adult Sprague-Dawley rats. In contrast, the Phase IV variant of strain L-84 was inactive in cough induction, as was strain BP 357, a transposon-insertion mutant which is deficient only in pertussis toxin (PT). Strain BPM 1809, which lacks only the...

Topics

Animals
Antibodies, Bacterial
Bordetella bronchiseptica
Bordetella pertussis
Cough
Diphtheria-Tetanus-Pertussis Vaccine
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Immunoglobulin G
Male
Microspheres

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Rats

Rats, Sprague-Dawley

Vaccination

Whooping Cough

Source

Identifiers

PMID: 8176718
DOI: 10.1099/00222615-40-5-307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8176718-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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