Article
Evidence for prebudding arrest of ER export in animal cell mitosis and its role in generating Golgi partitioning intermediates.
Traffic (Copenhagen, Denmark) - 1 May 2001
Prescott A R, Farmaki T, Thomson C, James J, Paccaud J P, Tang B L, Hong W, Quinn M, Ponnambalam S, Lucocq J
Abstract excerpt
During mitosis the interconnected Golgi complex of animal cells breaks down to produce both finely dispersed elements and discrete vesiculotubular structures. The endoplasmic reticulum (ER) plays a controversial role in generating these partitioning intermediates and here we highlight the importance of mitotic ER export arrest in this process. We show that experimental inhibition of ER export (by microinjecting...
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