Article
Rab1 and Ca2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport.
The Journal of cell biology - 1 Apr 1994
Pind S N, Nuoffer C, McCaffery J M, Plutner H, Davidson H W, Farquhar M G, Balch W E
Abstract excerpt
Members of the rab/YPT1/SEC4 gene family of small molecular weight GTPases play key roles in the regulation of vesicular traffic between compartments of the exocytic pathway. Using immunoelectron microscopy, we demonstrate that a dominant negative rab1a mutant, rab1a(N124I), defective for guanine...
Topics
- Animals
- Biological Transport
- Calcium
- Capsid
- Cell Line
- Endoplasmic Reticulum
- GTP-Binding Proteins
- Glycoproteins
- Golgi Apparatus
- Guanosine 5'-O-(3-Thiotriphosphate)
- Guanosine Diphosphate
- Guanosine Triphosphate
- Membrane Glycoproteins
- Microscopy, Immunoelectron
- Mutation