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Article

A Rab2 mutant with impaired GTPase activity stimulates vesicle formation from pre-Golgi intermediates.

Molecular biology of the cell - 1 Jun 1999

Tisdale E J

Abstract excerpt

Rab2 immunolocalizes to pre-Golgi intermediates (vesicular-tubular clusters [VTCs]) that are the first site of segregation of anterograde- and retrograde-transported proteins and a major peripheral site for COPI recruitment. Our previous work showed that Rab2 Q65L (equivalent to Ras Q61L) inhibited endoplasmic reticulum (ER)-to-Golgi transport in vivo. In this study, the biochemical properties of Rab2 Q65L were...

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Identifiers

PMID: 10359600
DOI: 10.1091/mbc.10.6.1837
PMCID: PMC25379

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