Article
A Rab2 mutant with impaired GTPase activity stimulates vesicle formation from pre-Golgi intermediates.
Molecular biology of the cell - 1 Jun 1999
Tisdale E J
Abstract excerpt
Rab2 immunolocalizes to pre-Golgi intermediates (vesicular-tubular clusters [VTCs]) that are the first site of segregation of anterograde- and retrograde-transported proteins and a major peripheral site for COPI recruitment. Our previous work showed that Rab2 Q65L (equivalent to Ras Q61L) inhibit...
Topics
- Animals
- Biological Transport
- Cell Line
- Coated Vesicles
- Coatomer Protein
- Dose-Response Relationship, Drug
- Endoplasmic Reticulum
- Enzyme Inhibitors
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Golgi Apparatus
- Mannose-Binding Lectins
- Membrane Glycoproteins
- Membrane Proteins
- Microtubule-Associated Proteins
- Mutation
- Naphthalenes
- Rats