Article
Cloning, structure, cellular localization, and possible function of the tumor suppressor gene lethal(3)malignant blood neoplasm-1 of Drosophila melanogaster.
Developmental biology - 1 May 1994
Konrad L, Becker G, Schmidt A, Klöckner T, Kaufer-Stillger G, Dreschers S, Edström J E, Gateff E
Abstract excerpt
The tumor suppressor gene, lethal(3)malignant blood neoplasm-1+, of Drosophila melanogaster is required for the differentiation of the phagocytic blood-cell type, the plasmatocyte. In the homozygously mutated state it causes the malignant transformation of these blood cells. We present here the c...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Blood Cells
- Cell Transformation, Neoplastic
- Chromosome Mapping
- Cloning, Molecular
- DNA, Complementary
- Drosophila melanogaster
- Genes, Tumor Suppressor
- Molecular Sequence Data
- RNA, Messenger