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Article

Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2012

Poirier Christophe, Berdyshev Evgeny V, Dimitropoulou Christiana, Bogatcheva Natalia V, Biddinger Paul W, Verin Alexander D

Abstract excerpt

Neutral sphingomyelinase 2 (nSMase2) upregulation was recently demonstrated to serve as a molecular link between smoke inhalation and emphysematous changes in lungs. Here we report that nSMase2 deficit impairs lung development in mice. We have shown previously that fragilitas ossium (fro) mice ca...

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Identifiers

PMID: 22945695
DOI: 10.1007/s00335-012-9419-x
PMCID: PMC4046642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22945695-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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