Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover.

doi:10.1042/CS20210713

Article

Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover.

Clinical science (London, England : 1979) - 26 Nov 2021

Corkill Dominic J, Hunt Alan N, Hinrichs Mary Jane, White Nicholas, Rebelatto Marlon, Roskos Lorin, Nys Josquin, Scott Alison, Robinson Matthew J, Ryan Patricia, Postle Anthony D, Sleeman Matthew A

Abstract excerpt

Granulocyte macrophage colony stimulating factor (GM-CSF) is a key participant in, and a clinical target for, the treatment of inflammatory diseases including rheumatoid arthritis (RA). Therapeutic inhibition of GM-CSF signalling using monoclonal antibodies to the α-subunit of the GM-CSF receptor (GMCSFRα) has shown clear benefit in patients with RA, giant cell arteritis (GCAs) and some efficacy in severe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover.

Abstract excerpt

Topics

Related research