Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of CD4+ regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Nov 2021

Li Yongqiang, Xu Mingkai, Li Yansheng, Zhang Zhichun, Gu Wu, Halimu Gulinare, Li Yuqi, Zhang Huiwen, Zhang Chenggang

Abstract excerpt

As a member of superantigens, Staphylococcal Enterotoxin C2 (SEC2) can potently activate T cells expressing specific Vβ repertoires and has been applied in clinic for tumor immunotherapy in China for more than 20 years. However, excessive activation of T cells by over-stimulation with superantigen are always followed by eliciting regulatory T cells (Tregs) induction and functional immunosuppression, which brings...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enterotoxins
Share to Interleukin-2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to NFATC Transcription Factors

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Smad3 Protein

Share to STAT5 Transcription Factor

Share to T-Lymphocytes, Regulatory

Share to Transcription Factor AP-1

Source

Identifiers

PMID: 34560552
DOI: 10.1016/j.biopha.2021.112204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of CD4+ regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways.PMID 34560552Read ↗

Staphylococcal enterotoxin C2 mutant drives T lymphocyte activation through PI3K/mTOR and NF-ĸB signaling pathways.Semantic proximity Read ↗

T-cell proliferation and antitumour activities of a truncated mutant of staphylococcal enterotoxin C2 with decreased cytokine secretion.Semantic proximity Read ↗

Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.Semantic proximity Read ↗

Enhancement of antitumor response of staphylococcal enterotoxin C2 mutant 2M-118 by promoting cell-mediated antitumor immunity.Semantic proximity Read ↗

Update on Staphylococcal Superantigen-Induced Signaling Pathways and Therapeutic InterventionsSemantic proximity Read ↗

Induction of Immunosuppressive CD8+CD25+FOXP3+ Regulatory T Cells by Suboptimal Stimulation with Staphylococcal Enterotoxin C1.Semantic proximity Read ↗

Granzyme B and perforin produced by SEC2 mutant-activated human CD4+ T cells and CD8+ T cells induce apoptosis of K562 leukemic cells by the mitochondrial apoptotic pathway.Semantic proximity Read ↗

The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cellsSemantic proximity Read ↗

Putative staphylococcal enterotoxin possesses two common structural motifs for MHC-II bindingSemantic proximity Read ↗

A mutant of staphylococcal enterotoxin C devoid of bacterial superantigenic activity elicits a Th2 immune response for protection against Staphylococcus aureus infection.Semantic proximity Read ↗

Combined activation of murine lymphocytes with staphylococcal enterotoxin and interleukin-2 results in additive cytotoxic activity.Semantic proximity Read ↗

Superantigens, a Paradox of the Immune ResponseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.