Article
Pediatric oncologist willingness to offer germline TP53 testing in osteosarcoma.
Cancer - 15 Mar 2018
Shaul Eliana, Roth Michael, Lo Yungtai, Geller David S, Hoang Bang, Yang Rui, Malkin David, Gorlick Richard, Gill Jonathan
Abstract excerpt
BACKGROUND: Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome caused by mutations in the tumor-suppressor gene TP53. Osteosarcoma is a sentinel cancer in LFS. Prior studies using Sanger sequencing platforms have demonstrated that 3% of individuals with osteosarcoma harbor a mutation in TP53. New data from next-generation sequencing have demonstrated that 3.8% of patients with osteosarcoma have a...
Topics
- Adolescent
- Child
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation
- Humans
- Li-Fraumeni Syndrome
- Male
- Oncologists
- Osteosarcoma
- Pediatricians
- Practice Patterns, Physicians'
- Surveys and Questionnaires
- Tumor Suppressor Protein p53