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Article

Germ-line genetic variation of TP53 in osteosarcoma.

Pediatric blood & cancer - 1 Jul 2007

Savage Sharon A, Burdett Laura, Troisi Rebecca, Douglass Chester, Hoover Robert N, Chanock Stephen J

Abstract excerpt

BACKGROUND: Osteosarcoma (OS) has been well described in individuals with germ-line TP53 mutations (Li-Fraumeni Syndrome) but typically occurs sporadically in adolescents and young adults. Single nucleotide polymorphisms (SNPs), the most common germ-line genetic variation, have been associated with risk for other types of cancer. We hypothesized that genetic variation in TP53 could be associated with OS risk...

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Identifiers

PMID: 17096406
DOI: 10.1002/pbc.21077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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