Article
A fairly conserved epitope on the hemagglutinin of influenza A (H3N2) virus with variable accessibility to neutralizing antibody.
Virology - 1 Oct 1995
Vanlandschoot P, Beirnaert E, Dewilde S, Saelens X, Bestebroer T, De Jong J, Jou W M, Fiers W
Abstract excerpt
A monoclonal antibody LMBH5 was derived from mice which had been immunized with A/Victoria/3/75 (H3N2)-type recombinant, secreted hemagglutinin (HA), and were subsequently challenged with a potentially lethal dose of X31 [A/Aichi/2/68 (H3N2) x A/PR/8/34 (H1N1)] virus. LMBH5 reacted strongly with...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Epitopes
- Genes, Viral
- Hemagglutination Tests
- Hemagglutinins, Viral
- Humans
- Hydrogen-Ion Concentration
- Influenza A Virus, H3N2 Subtype
- Influenza A virus
- Mice
- Mutation
- Neutralization Tests
- Protein Conformation
- Species Specificity
- Trypsin
- Viral Structural Proteins