Article
Prediction of genetic risks from segregation analyses of morbid risks.
Human heredity - 1 Jan 2000
Shields D C, Marlow A J, Houlston R S, Eccles D M, Morton N E
Abstract excerpt
Segregation analysis provides a genetic model of disease based upon morbid risks in age-specific classes, from which the model derives genotype-specific morbid risks. In the absence of disease-specific mortality each morbid risk is a cumulative incidence (age-specific penetrance). If disease-specific mortality reduces the number of affected in the older classes, the morbid risk is less than the corresponding...
Topics
- Genetic Diseases, Inborn
- Genotype
- Humans
- Models, Genetic
- Predictive Value of Tests
- Probability
- Risk Factors