Article
Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis.
Clinical and experimental rheumatology - 1 Jan 2000
Singal D P, Ye M, Qiu X, D'Souza M
Abstract excerpt
The human major histocompatibility complex (MHC) contains two closely related genes (TAP) that encode a family of transporter proteins. It is known that the TAP genes, like other MHC (class I and class II) genes, are polymorphic. In this study we investigated the polymorphisms in the ATP-binding domain of the TAP2 gene and examined the relationship of these polymorphisms to susceptibility to rheumatoid arthritis...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Adenosine Triphosphate
- Alleles
- Arthritis, Rheumatoid
- Base Sequence
- Binding Sites
- Carrier Proteins
- Genes
- HLA-D Antigens
- HLA-DR Antigens