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Article

Association of TAP2 polymorphism with rheumatoid arthritis is secondary to allelic association with HLA-DRB1.

Arthritis and rheumatism - 1 Apr 1994

Marsal S, Hall M A, Panayi G S, Lanchbury J S

Abstract excerpt

OBJECTIVE: To study polymorphisms of the newly described TAP2 locus in rheumatoid arthritis (RA) and to analyze their relationship with HLA-DRB1 alleles previously implicated in the development of the disease. METHODS: TAP2 polymorphic residues at 3 sites, Val/Ile-379, Ala/Thr-565, and Ala/Thr-665, were characterized by amplification refractory mutation system polymerase chain reaction in 185 RA patients and 48...

Topics

Adult
Alleles
Amino Acid Sequence
Arthritis, Rheumatoid
Base Sequence
Genotype
HLA-DR Antigens
HLA-DR4 Antigen
HLA-DRB1 Chains
Histocompatibility Antigens Class II
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Polymorphism, Genetic

Random Allocation

Source

Identifiers

PMID: 8147927
DOI: 10.1002/art.1780370410

Genes

TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8147927-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Association of TAP2 polymorphism with rheumatoid arthritis is secondary to allelic association with HLA-DRB1.PMID 8147927Read ↗

Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis.Semantic proximity Read ↗

TAP2 alleles in inflammatory arthritis.Semantic proximity Read ↗

TAP2D is associated with HLA-B44 and DR4 and may contribute to rheumatoid arthritis and Felty's syndrome susceptibility.Semantic proximity Read ↗

TAP1 and TAP2 gene polymorphism in rheumatoid arthritis in a population in eastern France.Semantic proximity Read ↗

Analysis of the MHC-encoded transporters TAP1 and TAP2 in rheumatoid arthritis: linkage with DR4 accounts for the association with a minor TAP2 allele.Semantic proximity Read ↗

Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis.Semantic proximity Read ↗

Peptide transporter genes (TAP) polymorphisms and genetic susceptibility to rheumatoid arthritis.Semantic proximity Read ↗

Polymorphism of human major histocompatibility complex-encoded transporter associated with antigen processing (TAP) genes and susceptibility to juvenile rheumatoid arthritis.Semantic proximity Read ↗

Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA–DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage‐specific type II collagen in early rheumatoid arthritisSemantic proximity Read ↗

Association of TAP2 gene polymorphisms in Chinese patients with rheumatoid arthritis.Semantic proximity Read ↗

HLA-DPB1*0201 is associated with particular clinical features of rheumatoid arthritis.Semantic proximity Read ↗

Polymorphism of TAP1 and TAP2 in Japanese patients with rheumatoid arthritis.Semantic proximity Read ↗

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