Article

Investigation of a selective transglutaminase 2 antagonist as a novel therapeutic agent for cystic fibrosis

2021-01-01

Abstract excerpt

Cystic fibrosis (CF) is a genetic disorder, characterised by the presence of a dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) protein. Currently approved therapeutic compounds all act by targeting CFTR directly. Yet, emerging evidence suggests that the proteostasis network within CF airway epithelial cells is severely disrupted, leading to fibrotic alterations of the extracellular matrix...

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Literature Corpus work: 65df5f48-6547-5829-addb-0dab91a28546
DOI: 10.48780/publications.aston.ac.uk.00043040

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