Article
Mutational processes of simple-sequence repeat loci in human populations.
Proceedings of the National Academy of Sciences of the United States of America - 12 Apr 1994
Di Rienzo A, Peterson A C, Garza J C, Valdes A M, Slatkin M, Freimer N B
Abstract excerpt
Mutational processes of simple sequence repeats (SSRs) in complex genomes are poorly understood. We examined these processes by introducing a two-phase mutation model. In this model, most mutations are single-step changes, but infrequent large jumps in repeat number also occur. We used computer s...
Topics
- Gene Frequency
- Genetic Markers
- Genetics, Population
- Humans
- Italy
- Mutation
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid