Article
Mobile elements reveal small population size in the ancient ancestors of Homo sapiens.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2010
Huff Chad D, Xing Jinchuan, Rogers Alan R, Witherspoon David, Jorde Lynn B
Abstract excerpt
The genealogies of different genetic loci vary in depth. The deeper the genealogy, the greater the chance that it will include a rare event, such as the insertion of a mobile element. Therefore, the genealogy of a region that contains a mobile element is on average older than that of the rest of the genome. In a simple demographic model, the expected time to most recent common ancestor (TMRCA) is doubled if a...
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