Article
Small insertions are more deleterious than small deletions in human genomes.
Human mutation - 1 Dec 2013
Huang Shengfeng, Li Jie, Xu Anlong, Huang Guangrui, You Leiming
Abstract excerpt
Although lines of evidence suggest that small insertions and deletions differ in their mechanisms of formation, there remains the debate on whether natural selection acts differently on the two indel types. Currently available personal genomes and the 1000 Genomes Project permit population level and genome scale comparison of the selection regimes on the two indel types. We first developed a statistical model to...
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