Structural insights and functional implications of choline acetyltransferase.

doi:10.1016/j.jsb.2004.06.005

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Article

Structural insights and functional implications of choline acetyltransferase.

Journal of structural biology - 1 Nov 2004

Govindasamy Lakshmanan, Pedersen Brenda, Lian Wei, Kukar Thomas, Gu Yunrong, Jin Shouguang, Agbandje-McKenna Mavis, Wu Donghai, McKenna Robert

Abstract excerpt

The biosynthetic enzyme for the neurotransmitter acetylcholine, choline acetyltransferase (ChAT) (E.C. 2.3.1.6), is essential for the development and neuronal activities of cholinergic systems involved in many fundamental brain functions. ChAT catalyzes the transfer of an acetyl group from acetyl-coenzyme A to choline to form the neurotransmitter acetylcholine. Since its discovery more than 60 years ago much...

Topics

Acetylcholine
Amino Acid Sequence
Animals
Binding Sites
Caenorhabditis elegans
Catalysis
Choline O-Acetyltransferase
Coenzyme A
Crystallography, X-Ray
Humans
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Models, Chemical

Models, Molecular

Molecular Sequence Data

Mutation

Protein Conformation

Protein Structure, Tertiary

Source

Open in PubMed

Identifiers

PMID: 15477102
DOI: 10.1016/j.jsb.2004.06.005

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