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Article

Molecular aspects of methicillin resistance in <i>Staphylococcus aureus</i>

1 Jan 1994

Abstract excerpt

All clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates examined so far contain the mecA gene, a 2130bp stretch of DNA of non-staphylococcal origin which, together with a larger block (up to 40-60 Kb) of 'foreign' DNA, is incorporated into the staphylococcal chromosome. mecA encodes for the 78 Kd penicillin-binding protein (PBP) 2A, which has very low affinity for beta-lactam antibiotics. The...

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PMID: 8157576
DOI: 10.1093/jac/33.1.7

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