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Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications

1 Oct 1997

Abstract excerpt

Methicillin resistance in staphylococci is determined by mec, composed of 50 kb or more of DNA found only in methicillin-resistant strains. mec contains mecA, the gene for penicillin-binding protein 2a (PBP 2a); mecI and mecR1, regulatory genes controlling mecA expression; and numerous other elements and resistance determinants. A distinctive feature of methicillin resistance is its heterogeneous expression....

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PMID: 9336672
DOI: 10.1128/cmr.10.4.781

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