Article
Molecular basis of low-penetrance retinoblastoma.
Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Nov 2001
Harbour J W
Abstract excerpt
Retinoblastoma is a malignant tumor of the retina that occurs primarily in young children as a result of mutations in the retinoblastoma gene (RB), the first tumor suppressor gene to be identified. In about 35% to 40% of patients with retinoblastoma, an RB gene mutation is present in the germline, resulting in hereditary transmission of the disease. Most families with hereditary retinoblastoma demonstrate...
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