Antagonism between bactericidal activities of 4-quinolones and coumarins gives insight into 4-quinolone killing mechanisms.

Article

Antagonism between bactericidal activities of 4-quinolones and coumarins gives insight into 4-quinolone killing mechanisms.

Microbios - 1 Jan 1994

Howard B M, Pinney R J, Smith J T

Abstract excerpt

At concentrations exceeding their MICs, novobiocin and coumermycin antagonised the bactericidal activities of nalidixic acid, ciprofloxacin, ofloxacin and norfloxacin against Escherichia coli KL16. The sensitivities to killing by ciprofloxacin of four mutant derivatives of KL16 carrying gyrA, nal...

Topics

Aminocoumarins
Anti-Infective Agents
Ciprofloxacin
Coumarins
DNA Topoisomerases, Type II
Escherichia coli
Genes, Bacterial
Microbial Sensitivity Tests
Mutation
Nalidixic Acid
Norfloxacin
Novobiocin
Ofloxacin
Rifampin

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