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Article

Polymorphism in the metabolism of drugs, including antidepressant drugs: comments on phenotyping.

Journal of psychiatry & neuroscience : JPN - 1 Jan 1994

Coutts R T

Abstract excerpt

In neurochemistry there are advantages in determining how patients are likely to react to psychoactive drugs prior to the commencement of drug therapy. Explanations of a patient's nonresponse, or unexpected adverse reactions to drugs are required. In many instances, a knowledge of the drug metabolism status of a patient can be helpful in the selection of a drug and its dosage regimen, and in the prediction of...

Topics

Clomipramine
Cytochromes
Dealkylation
Depressive Disorder
Desipramine
Dextromethorphan
Drug Interactions
Female
Humans
Hydroxylation
Imipramine
Isoenzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mephenytoin

Nortriptyline

Phenotype

Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 8148364
PMCID: PMC1188560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8148364-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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