Article
Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8.
The American journal of physiology - 1 May 1996
Zeng D, Kyle J W, Martin R L, Ambler K S, Hanck D A
Abstract excerpt
RT4-B is one of several cell lines derived from a multipotent stem cell line, RT4-AC, which originated from a rat peripheral neurotumor. Based on Northern blot and ribonuclease protection experiments, RT4-B8 cells have been proposed to express rat cardiac Na channel mRNA as the major isoform. We report here direct electrophysiological evidence that the expressed voltage-gated Na channels in the RT4-B8 cell line...
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