Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A putative role for c-Fos in the pathophysiology of Paget's disease.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 1999

Beedles K E, Sharpe P T, Wagner E F, Grigoriadis A E

Abstract excerpt

The molecular mechanisms underlying Paget's disease and subsequent osteosarcoma formation are not well understood. In this study, we aim to delineate the function of the c-Fos oncogene in Paget's disease using transgenic mice, based on previous findings that c-Fos is highly expressed in Pagetic osteoclasts and that c-Fos is an essential gene for osteoclast differentiation and skeletal neoplasia. We have generated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Phosphatase
Share to Bone and Bones

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chondrocytes

Share to In Situ Hybridization

Share to Matrix Metalloproteinase 9

Share to Osteitis Deformans

Share to Proto-Oncogene Proteins c-fos

Share to Tartrate-Resistant Acid Phosphatase

Source

Identifiers

PMID: 10510209
DOI: 10.1002/jbmr.5650140206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A putative role for c-Fos in the pathophysiology of Paget's disease.PMID 10510209Read ↗

c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone RemodelingSemantic proximity Read ↗

Activation of NFAT Signal In Vivo Leads to Osteopenia Associated with Increased Osteoclastogenesis and Bone-Resorbing ActivitySemantic proximity Read ↗

Osteoblasts are target cells for transformation in c-fos transgenic mice.Semantic proximity Read ↗

Transgenic mice that express Cre recombinase in osteoclastsSemantic proximity Read ↗

Fosl1 is a transcriptional target of c-Fos during osteoclast differentiationSemantic proximity Read ↗

Autoamplification of NFATc1 expression determines its essential role in bone homeostasisSemantic proximity Read ↗

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease.Semantic proximity Read ↗

Expression of Measles Virus Nucleocapsid Protein in Osteoclasts Induces Paget's Disease-Like Bone Lesions in MiceSemantic proximity Read ↗

Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiationSemantic proximity Read ↗

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1Semantic proximity Read ↗

Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice.Semantic proximity Read ↗

Mutant p62P392L stimulation of osteoclast differentiation in Paget's disease of bone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.