Molecular analysis of human platelet antigen system 1 antigen on single cells can be applied to preimplantation genetic diagnosis for prevention of alloimmune thrombocytopenia.

doi:10.1016/s0002-9378(94)70287-x

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Article

Molecular analysis of human platelet antigen system 1 antigen on single cells can be applied to preimplantation genetic diagnosis for prevention of alloimmune thrombocytopenia.

American journal of obstetrics and gynecology - 1 Mar 1994

Van den Veyver I B, Chong S S, Kristjansson K, Snabes M C, Moise K J, Hughes M R

Abstract excerpt

OBJECTIVE: Our purpose was to develop a molecular assay to determine the human platelet antigen system 1 status on single nucleated cells, including human blastomeres. STUDY DESIGN: Eighty single cultured lymphoblasts of known human platelet antigen system 1 genotype and 24 media blanks were mixe...

Topics

Antigens, Human Platelet
Base Sequence
Chromosomes, Human, Pair 17
DNA Primers
Female
Fetal Diseases
Genetic Counseling
Genotype
Humans
Integrin beta3
Isoantibodies
Male
Molecular Sequence Data
Polymerase Chain Reaction
Pregnancy

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Open in PubMed

Identifiers

PMID: 8141206
DOI: 10.1016/s0002-9378(94)70287-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8141206-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Prenatal Diagnosis

Purpura, Thrombocytopenic

Sensitivity and Specificity