Article
Low-frequency human platelet antigens as triggers for neonatal alloimmune thrombocytopenia.
Transfusion - 1 May 2014
Peterson Julie A, Gitter Maria, Bougie Daniel W, Pechauer Shannon, Hopp Kathleen A, Pietz Brad, Szabo Aniko, Curtis Brian R, McFarland Janice, Aster Richard H
Abstract excerpt
BACKGROUND: Twenty-four low-frequency human platelet antigens (LFHPAs) have been implicated as immunogens in neonatal alloimmune thrombocytopenia (NAIT). We performed studies to define more fully how often these antigens trigger maternal immunization leading to NAIT. STUDY DESIGN AND METHODS: In a Phase 1 study, fathers of selected NAIT cases not resolved by serologic testing but thought to have a high likelihood...
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