Article
Mass-scale high-throughput multiplex polymerase chain reaction for human platelet antigen single-nucleotide polymorphisms screening of apheresis platelet donors.
Transfusion - 1 Sept 2011
Shehata Nadine, Denomme Gregory A, Hannach Barbara, Banning Nancy, Freedman John
Abstract excerpt
BACKGROUND: Treatment with human platelet antigen (HPA)-matched platelets (PLTs) is the optimal therapy for bleeding secondary to neonatal alloimmune thrombocytopenia. Recent advances in high-throughput DNA-based blood group and PLT antigen genotyping have made it possible to screen plateletpheresis donors for potential HPA-matched PLT transfusion. STUDY DESIGN AND METHODS: This prospective study evaluated...
Topics
- Antigens, Human Platelet
- Blood Donors
- Donor Selection
- Humans
- Plateletpheresis
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Prospective Studies
- Thrombocytopenia, Neonatal Alloimmune