Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A V740L mutation in glycoprotein IIb defines a novel epitope (War) associated with fetomaternal alloimmune thrombocytopenia.

Transfusion - 1 Sept 2013

Poles Anthony, Woźniak Marcin J, Walser Piers, Ridgwell Kay, Fitzgerald Joan, Green Ann, Gilmore Ruth, Lucas Geoff

Abstract excerpt

BACKGROUND: Most recently described human platelet antigens (HPAs) have been detected in cases of fetomaternal alloimmune thrombocytopenia (FMAIT) where the mother has been immunized against a low-frequency antigen that the fetus has inherited from the father. Low-frequency antigens are not represented in normal panel platelets (PLTs) and antibody detection and identification in such cases requires incubation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Human Platelet
Share to CD36 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitopes

Share to Flow Cytometry

Share to Integrin alpha2

Share to Integrin beta3

Share to Molecular Dynamics Simulation

Share to Pregnancy

Source

Identifiers

PMID: 23305224
DOI: 10.1111/trf.12067

Genes

ITGB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A V740L mutation in glycoprotein IIb defines a novel epitope (War) associated with fetomaternal alloimmune thrombocytopenia.PMID 23305224Read ↗

Severe fetomaternal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-1a in a mother with a rare and silenced ITGB3*0101 (GPIIIa) allele.Semantic proximity Read ↗

Immunization against a low-frequency human platelet alloantigen in fetal alloimmune thrombocytopenia is not a single event: characterization by the combined use of reference DNA and novel allele-specific cell lines expressing recombinant antigens.Semantic proximity Read ↗

Low-frequency human platelet antigens as triggers for neonatal alloimmune thrombocytopenia.Semantic proximity Read ↗

Fetal and neonatal alloimmune thrombocytopenia: Current pathophysiological insights and perspectives for future diagnostics and treatmentSemantic proximity Read ↗

Alloantibodies against low-frequency human platelet antigens do not account for a significant proportion of cases of fetomaternal alloimmune thrombocytopenia: evidence from 1054 cases.Semantic proximity Read ↗

A single-nucleotide polymorphism in the human ITGB3 gene is associated with the platelet-specific alloantigen Va (HPA-17bw) involved in fetal maternal alloimmune thrombocytopenia.Semantic proximity Read ↗

New platelet glycoprotein polymorphisms causing maternal immunization and neonatal alloimmune thrombocytopenia.Semantic proximity Read ↗

Fetal-neonatal alloimmune thrombocytopenia and unexpected Glanzmann thrombasthenia carrier: report of two cases.Semantic proximity Read ↗

HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrinsSemantic proximity Read ↗

HPA-5 typing discrepancy reveals an Ile503Leu substitution in platelet GPIa (α2 integrin).Semantic proximity Read ↗

Assessment of human platelet antigen (HPA)-1a alloimmunisation in women identified at increased risk for foetal and neonatal alloimmune thrombocytopaenia (FNAIT): a prospective, natural history studySemantic proximity Read ↗

Molecular insight into human platelet antigens: structural and evolutionary conservation analyses offer new perspective to immunogenic disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.