Article
Antitumor activity of free and liposome-entrapped annamycin, a lipophilic anthracycline antibiotic with non-cross-resistance properties.
Cancer research - 15 Mar 1994
Zou Y, Ling Y H, Van N T, Priebe W, Perez-Soler R
Abstract excerpt
The lipophilic anthracycline antibiotic annamycin (Ann) was entrapped in liposomes of different size [median diameter: 1.64 microns, multilamellar liposomal Ann (L-Ann); 0.030 micron, small unilamellar Ann (S-Ann)] with > 90% entrapment efficiency and tested in vitro against four pairs of sensiti...
Topics
- Animals
- Antibiotics, Antineoplastic
- Antineoplastic Agents
- Chemical Phenomena
- Chemistry, Physical
- Doxorubicin
- Drug Resistance
- Drug Screening Assays, Antitumor
- Humans
- KB Cells
- Leukemia P388
- Liposomes
- Lung Neoplasms
- Male
- Melanoma, Experimental
- Mice
- Mice, Inbred C57BL
- Mice, Nude