Article
Analysis of amino acid substitution during divergent evolution: the 400 by 400 dipeptide substitution matrix.
Biochemical and biophysical research communications - 15 Mar 1994
Gonnet G H, Cohen M A, Benner S A
Abstract excerpt
Most formal methods for analyzing the divergent evolution of protein sequences assume a Markov model where position i in a polypeptide chain undergoes amino acid substitution independently from position i + 1. The large number of aligned homologous sequence pairs available from the exhaustive matching of the protein sequence database makes it possible to examine this assumption empirically. We have constructed a...
Topics
- Amino Acid Sequence
- Biological Evolution
- Conserved Sequence
- Dipeptides
- Genetic Variation
- Information Systems
- Markov Chains
- Models, Genetic
- Point Mutation
- Proteins