Alignment and comparison of multiple related DNA sequences can be improved by consideration of known patterns of mutation.

doi:10.3109/10425179309020823

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Article

Alignment and comparison of multiple related DNA sequences can be improved by consideration of known patterns of mutation.

DNA sequence : the journal of DNA sequencing and mapping - 1 Jan 1993

Bains W

Abstract excerpt

The rate at which bases are replaced in mammalian DNA is influenced by the sequence involved. I have modified a multiple sequence alignment and comparison program to take account of the observed patterns of base replacement in mammals, and used the program to analyse 100 human Alu sequences. The...

Topics

Animals
Base Sequence
DNA
Databases, Factual
Genetic Variation
Hominidae
Humans
Mammals
Models, Genetic
Molecular Sequence Data
Mutation
Sequence Homology, Nucleic Acid

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