Article
[A characteristic of alcoholics with the atypical aldehyde dehydrogenase (ALDH2(2)--a relationship to other alcohol metabolizing enzymes].
Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence - 1 Feb 1994
Nakamura K, Iwahashi K, Suwaki H, Miyatake R, Matsuo Y, Ichikawa Y
Abstract excerpt
The series were composed of 59 alcoholics. All the subjects fulfilled the DSM-III-R criteria for alcohol dependency. We investigated the genotype at ALDH2. 6 patients were heterozygous ALDH2(1)/ALDH2(2). We determined the genotypes at ADH2, ADH3 and P-4502E1 about 6 patients. 5 patients had ADH2(1)/ADH2(1) allele. 2 patients had P-450E1*C2. We found a genetic characteristic about alcoholics with the heterozygous...
Topics
- Alcohol Dehydrogenase
- Alcoholism
- Aldehyde Dehydrogenase
- Alleles
- Base Sequence
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Genotype
- Heterozygote
- Humans