Article
[Association between alcoholics and the genotypes of ALDH2, ADH2, ADH3 as well as P-4502E1].
Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence - 1 Feb 1995
Nakamura K, Suwaki H, Matsuo Y, Ichikawa Y, Miyatake R, Iwahashi K
Abstract excerpt
We examined the genotypes of ALDH2, ADH2, ADH3 and P-4502E1 loci of alcoholics and nonalcoholics. Also we compared the frequencies of the homozygous ALDH2*1/1 genotype and heterozygous ALDH2*1/2 genotypes in alcoholics. Our study reported differences in the allelic frequencies of ALDH2, ADH2 and ADH3 loci between alcoholics and nonalcoholics. For alcoholics, it was indicated that ADH2 and ADH3 plays an important...
Topics
- Alcohol Dehydrogenase
- Alcoholism
- Aldehyde Dehydrogenase
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Gene Frequency
- Genotype
- Humans
- Oxidoreductases, N-Demethylating