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Article

Complex segregation analysis of antibodies to thyroid peroxidase in Old Order Amish families.

American journal of medical genetics - 1 Sept 1993

Pauls D L, Zakarija M, McKenzie J M, Egeland J A

Abstract excerpt

Autoimmune thyroid disease (AITD) may be characterized by the measurement in serum of antibodies to thyroid peroxidase. A population of Old Order Amish individuals and families was investigated to determine the prevalence of these antibodies and to examine hypotheses about the mode of transmission of thyroid antibodies. Complex segregation analyses were performed on 4 large multigenerational Old Order Amish...

Topics

Adolescent
Adult
Autoantibodies
Autoimmunity
Child
Child, Preschool
Disease Susceptibility
Ethnicity
Female
Genetic Predisposition to Disease
Humans
Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Iodide Peroxidase

Male

Models, Genetic

Thyroiditis, Autoimmune

Source

Identifiers

PMID: 8135284
DOI: 10.1002/ajmg.1320470315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8135284-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Complex segregation analysis of antibodies to thyroid peroxidase in Old Order Amish families.PMID 8135284Read ↗

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A genome-wide scan for autoimmune thyroiditis in the Old Order Amish: replication of genetic linkage on chromosome 5q11.2-q14.3.Semantic proximity Read ↗

Two different mutations in the thyroid peroxidase gene of a large inbred Amish kindred: power and limits of homozygosity mapping.Semantic proximity Read ↗

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