Article
Genetic analysis of serum alanine transaminase activity in normal and hepatitis C virus-infected chimpanzees: an application of research-oriented genetic management.
Laboratory animal science - 1 Feb 1996
Williams-Blangero S, Blangero J, Murthy K K, Lanford R E
Abstract excerpt
The hepatic enzyme alanine transaminase (ALT) is a diagnostic marker for liver damage but has a considerable degree of normal variation. We used complex segregation analysis to determine whether evidence exists for major genic determination of normal ALT values in an important animal model, the c...
Topics
- Alanine Transaminase
- Animals
- Ape Diseases
- Biomarkers
- Chi-Square Distribution
- Disease Models, Animal
- Female
- Gene Frequency
- Genotype
- Hepacivirus
- Hepatitis C
- Likelihood Functions
- Male
- Pan troglodytes
- Pedigree
- Reference Values