Article
A genome-wide scan for autoimmune thyroiditis in the Old Order Amish: replication of genetic linkage on chromosome 5q11.2-q14.3.
The Journal of clinical endocrinology and metabolism - 1 Mar 2003
Allen Elsie M, Hsueh Wen-Chi, Sabra Mona M, Pollin Toni I, Ladenson Paul W, Silver Kristi D, Mitchell Braxton D, Shuldiner Alan R
Abstract excerpt
Autoimmune thyroiditis (AITD) is a common disorder characterized by circulating antibodies to epitopes of thyroid tissue and hypothyroidism (Hashimoto's thyroiditis or AITD-hypothyroidism), although many subjects with AITD are euthyroid. Current evidence suggests that AITD is familial and polygenic. We studied AITD in a homogeneous founder Caucasian population, the Old Order Amish of Lancaster County,...
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