Article
Power of segregation analysis for detection of major gene effects on quantitative traits.
Genetic epidemiology - 1 Jan 1994
Borecki I B, Province M A, Rao D C
Abstract excerpt
The power to detect major gene effects by rejection of the "no major gene" null hypothesis against a mixed model alternative was determined in random samples of nuclear families over a variety of conditions. Benchmarks have been developed using a varying number of families whose structure include...
Topics
- Bias
- Effect Modifier, Epidemiologic
- Genes, Dominant
- Genes, Recessive
- Genetic Variation
- Genetics, Population
- Homozygote
- Humans
- Likelihood Functions
- Models, Genetic
- Nuclear Family
- Phenotype
- Prevalence
- Sampling Studies