Evidence for genetic transmission of thyroid peroxidase autoantibody epitopic "fingerprints".

doi:10.1210/jcem.84.4.5639

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Article

Evidence for genetic transmission of thyroid peroxidase autoantibody epitopic "fingerprints".

The Journal of clinical endocrinology and metabolism - 1 Apr 1999

Jaume J C, Guo J, Pauls D L, Zakarija M, McKenzie J M, Egeland J A, Burek C L, Rose N R, Hoffman W H, Rapoport B, McLachlan S M

Abstract excerpt

Autoimmune thyroid disease is characterized by the tendency to cluster in families and by IgG class autoantibodies to antigens such as thyroid peroxidase (TPO). The epitopes recognized by polyclonal serum autoantibodies can be quantitatively fingerprinted using four recombinant human TPO autoantibodies (expressed as Fab) that define A and B domain epitopes in an immunodominant region. To determine whether these...

Topics

Autoantibodies
Epitopes
Female
Genes, Immunoglobulin
Humans
Iodide Peroxidase
Male
Pedigree
Phenotype
Thyroiditis, Autoimmune

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PMID: 10199790
DOI: 10.1210/jcem.84.4.5639

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