Article
Combined segregation and linkage analysis of Graves disease with a thyroid autoantibody diathesis.
American journal of human genetics - 1 Sept 1994
Shields D C, Ratanachaiyavong S, McGregor A M, Collins A, Morton N E
Abstract excerpt
Combined segregation and linkage analysis is a powerful technique for modeling linkage to diseases whose etiology is more complex than the effect of a well-described single genetic locus and for investigating the influence of single genes on various aspects of the disease phenotype. Graves diseas...
Topics
- Adolescent
- Adult
- Autoantibodies
- Chi-Square Distribution
- Child
- Discriminant Analysis
- Female
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Graves Disease
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- HLA-DR3 Antigen
- HLA-DR5 Antigen
- Humans
- Immunoglobulin Gm Allotypes