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Multi-level regulation of coelimycin synthesis in Streptomyces coelicolor A3(2)

27 Jun 2019

Abstract excerpt

Despite being a yellow pigment visible to the human eye, coelimycin (CPK) remained to be an undiscovered secondary metabolite for over 50 years of Streptomyces research. Although the function of this polyketide is still unclear, we now know that its "cryptic" nature is attributed to a very complex and precise mechanism of cpk gene cluster regulation in the model actinomycete S. coelicolor A3(2). It responds to...

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PMID: 31250060
DOI: 10.1007/s00253-019-09975-w

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