Article
Screening for familial defective apolipoprotein B-100 with improved U937 monocyte proliferation assay.
Clinical chemistry - 1 Mar 1994
Van den Broek A J, Hollaar L, Schaefer H I, Van der Laarse A, Schuster H, Defesche J C, Kastelein J J, Van 't Hooft F M
Abstract excerpt
Frostegård et al. (J Lipid Res 1990;31:37-44) demonstrated that the proliferation of the human monocyte cell line U937 is critically dependent on the uptake of low-density lipoprotein (LDL) via the apo B, E (LDL) receptor, a characteristic that was used to detect patients with familial defective...
Topics
- Apolipoprotein B-100
- Apolipoproteins B
- Cell Division
- Cell Line
- Humans
- Hyperlipoproteinemia Type II
- Leukocyte Count
- Lipoproteins, LDL
- Monocytes
- Mutation