Article
Screening for familial defective apolipoprotein B-100 with improved U937 monocyte proliferation assay.
Clinical chemistry - 1 Mar 1994
Van den Broek A J, Hollaar L, Schaefer H I, Van der Laarse A, Schuster H, Defesche J C, Kastelein J J, Van 't Hooft F M
Abstract excerpt
Frostegård et al. (J Lipid Res 1990;31:37-44) demonstrated that the proliferation of the human monocyte cell line U937 is critically dependent on the uptake of low-density lipoprotein (LDL) via the apo B, E (LDL) receptor, a characteristic that was used to detect patients with familial defective apolipoprotein B-100 (FDB). Here we applied this principle to develop a simple and reproducible assay for the detection...
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