Article
Enhanced bridging function and augmented monocyte adhesion by lipoprotein lipase N9: insights into increased risk of coronary artery disease in N9 carriers.
Atherosclerosis - 1 Feb 2003
Fisher Rachel M, Benhizia Ferdaous, Schreiber Renate, Makoveichuk Elena, Putt Wendy, Al-Haideri Maysoon, Deckelbaum Richard J, Olivecrona Gunilla, Humphries Steve E, Talmud Philippa J
Abstract excerpt
Lipoprotein lipase (LPL) is central to triacylglycerol (TG) metabolism, having both hydrolytic and bridging functions. The common LPL gene variant D9N is associated with raised TG, reduced HDL-cholesterol concentrations and increased risk of coronary artery disease (CAD). To investigate the functional basis for the phenotype in N9 carriers, CHO K1 cells were stably transfected with wild type (D9) or mutant (N9)...
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