Article
Analysis of novel apolipoprotein B mutations using a modified U937 cell line LDL binding assay.
Clinica chimica acta; international journal of clinical chemistry - 9 Dec 1996
Meng Q H, Pajukanta P, Ilmonen M, Schuster H, Schewe C K, Andersson L C, Tikkanen M J
Abstract excerpt
The U937 myelomonocyte proliferation assay can be used to detect patients with familial defective apolipoprotein B-100 (FDB). Previous studies have employed electronic cell counting to assess cell proliferation. We simplified the assay using 3H-thymidine incorporation DNA analysis to measure cell growth. We tested the modified method by analyzing the effects of different concentrations of native low density...
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