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Article

Activation of the human NPY gene during neuroblastoma cell differentiation: induced transcriptional activities of AP-1 and AP-2.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jan 1994

Andersson G, Påhlman S, Parrow V, Johansson I, Hammerling U

Abstract excerpt

During functional neuronal differentiation of human SH-SY5Y neuroblastoma cells, induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), the mRNA expression of c-fos and c-jun displayed a synchronous and biphasic type of induction for both mRNAs, with an early transient (30 to 120 min) and a later (> 8 h) more persistent increase. This was coupled to increased in vitro DNA binding activity of cFos/cJun AP-1...

Topics

Base Sequence
Cell Differentiation
Gene Expression Regulation, Neoplastic
Genes, fos
Genes, jun
Humans
In Vitro Techniques
Molecular Sequence Data
Neuroblastoma
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase C

Proto-Oncogene Proteins c-jun

RNA, Messenger

Tetradecanoylphorbol Acetate

Transfection

Source

Identifiers

PMID: 8123590

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8123590-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Activation of the human NPY gene during neuroblastoma cell differentiation: induced transcriptional activities of AP-1 and AP-2.PMID 8123590Read ↗

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