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Article

NF-kappaB site interacts with Sp factors and up-regulates the NR1 promoter during neuronal differentiation.

The Journal of biological chemistry - 23 Apr 2004

Liu Anguo, Hoffman Peter W, Lu Weiwei, Bai Guang

Abstract excerpt

The NR1 gene undergoes induction in neurogenesis mainly via promoter de-repression, and up-regulation during neuronal differentiation by undefined mechanism(s). Here, we show that in the distal region the NR1 promoter has an active NF-kappaB site sharing the consensus with the immunoglobulin (Ig)/human immunodeficiency virus NF-kappaB site. Mutation of this site significantly reduced NR1 promoter up-regulation...

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Identifiers

PMID: 14970236
DOI: 10.1074/jbc.M311267200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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