The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis.

doi:10.1038/bjc.1994.76

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Article

The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis.

British journal of cancer - 1 Mar 1994

Levine A J, Perry M E, Chang A, Silver A, Dittmer D, Wu M, Welsh D

Abstract excerpt

The p53 tumour-suppressor gene is mutated in 60% of human tumours, and the product of the gene acts as a suppressor of cell division. It is thought that the growth-suppressive effects of p53 are mediated through the transcriptional transactivation activity of the protein. Overexpression of the p5...

Topics

Animals
Gene Expression
Genes, p53
Humans
Mice
Mutagens
Mutation
Neoplasms
Point Mutation
Tumor Suppressor Protein p53

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