Article
Absence of linkage disequilibrium at amyloid precursor protein gene locus in Japanese familial Alzheimer's disease with 717Val-->Ile mutation.
Neuroscience letters - 12 Nov 1993
Tanaka H, Naruse S, Seki K, Onodera O, Kobayashi H, Miyatake T, Shibata A, Sakaki Y, Kamino K, Miki T
Abstract excerpt
To date, eleven independent FAD pedigrees with the 717Val-->Ile mutation have been identified. Interestingly, five pedigrees were of Japanese origin and four were of British origin. The apparent ethnic prediction of this mutation raises the possibility that there is a founder effect in these two...
Topics
- Alleles
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Humans
- Isoleucine
- Japan
- Linkage Disequilibrium
- Mutation
- Polymorphism, Genetic
- Valine